Clinical and molecular features of ovarian stimulation in peripubertal girls with mosaic Turner's syndrome - PubMed
11 hours ago
- #Peripubertal
- #Turner's syndrome
- #Ovarian stimulation
- Peripubertal girls with mosaic Turner's syndrome (TS) respond to ovarian stimulation (OS) similarly to adult females with normal ovarian reserve.
- Ovarian stimulation for oocyte freezing is a new approach for young TS patients, as ovarian tissue cryopreservation lacks proven efficacy due to diminished ovarian reserve.
- The study analyzed clinical and molecular features of OS in four peripubertal TS patients (ages 9, 12, 13, 15) compared to adult controls.
- All TS cases responded to gonadotropin stimulation, with successful retrieval and vitrification of mature oocytes.
- Molecular analysis showed similar FSH/LH receptor expression, steroidogenic enzyme activity, and hormone production in TS patients and controls.
- Limitations include a small sample size and lack of data on post-thaw oocyte viability and pregnancy outcomes.
- The study suggests OS for oocyte freezing could be a viable option for young mosaic TS patients with diminished ovarian reserve.