Mucosal-Penetrating Nanovaccine Enhances Mucosal and Systemic Immunity against Respiratory Syncytial Virus Infection - PubMed
5 hours ago
- #RSV
- #nanoparticle
- #mucosal vaccine
- Mucosal immunity is crucial for protection against respiratory infections but is challenging to achieve due to mucosal tissue complexity and immune tolerance.
- A hyaluronic acid (HA)-coated nanoparticulate vaccine (NHCF) containing RSV Pre-F protein and chitosan was developed to enhance mucus penetration and immune response.
- NHCF-GAMP, which includes 2,3-cGAMP as an agonist, showed superior performance in overcoming immune tolerance, producing high IgA and IgG titers, and recruiting immune cells.
- The NHCF-GAMP vaccine significantly reduced mucosal damage and viral load in mice challenged with RSV.
- The study highlights the importance of a well-designed antigen and agonist delivery system for effective mucosal vaccines.