Peroxisome Proliferator-Activated Receptor β/δ: A Link Between Metabolism, Inflammation, and Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease - PubMed
5 hours ago
- #Liver Fibrosis
- #MASLD
- #PPARβ/δ
- PPARβ/δ plays a role in preventing the progression of Metabolic dysfunction-associated steatotic liver disease (MASLD).
- MASLD ranges from isolated steatosis to metabolic dysfunction-associated steatohepatitis (MASH), characterized by hepatocyte ballooning and liver inflammation.
- PPARβ/δ is expressed in major liver cells and helps ameliorate insulin resistance, lipotoxicity, inflammation, and fibrosis.
- The review summarizes molecular mechanisms of PPARβ/δ in attenuating MASLD progression and discusses future research perspectives.