Engineering macrophages for effective and safe targeting of CD47 cancer cells in the tumor microenvironment - PubMed
5 hours ago
- #Macrophage Engineering
- #Solid Tumors
- #Immunotherapy
- Tumor-associated macrophages play a crucial role in the tumor microenvironment (TME), influencing both innate and adaptive immune responses.
- Macrophages can enhance antitumoral treatments through phagocytosis, tumoricidal activity, and adaptive immunity, but their inhibitory receptors can limit efficacy.
- Chimeric antigen receptor (CAR) macrophage therapy shows promise, with Du et al developing pArg1-CD47 CAR-Mφ for TME-specific activation, overcoming SIRPα inhibition.
- Preclinical models of breast and gastric cancer demonstrated significant tumor regression with minimal toxicity to erythrocytes.
- Translating macrophage engineering therapies from mice to humans remains a challenge but offers potential for safe and effective solid tumor treatments.