Identification of Pinostilbene as a natural STING agonist that triggers FTH1 degradation via K48-ubiquitination to induce ferroptosis in non-small cell lung cancer - PubMed
11 hours ago
- #NSCLC
- #STING agonist
- #Ferroptosis
- Pinostilbene identified as a natural STING agonist that induces ferroptosis in non-small cell lung cancer (NSCLC).
- Pinostilbene activates the STING/TBK1/IRF3 pathway, upregulating cytokines and enhancing sensitivity to RSL3-induced ferroptosis.
- Mechanistically, Pinostilbene promotes FTH1 degradation via K48-linked polyubiquitination, increasing labile iron pool for ferroptosis.
- In vivo, Pinostilbene shows antitumor efficacy alone and synergizes with RSL3, without systemic toxicity.
- Pinostilbene enhances antitumor immunity by upregulating cytokines, activating CD8+ T cells, and polarizing macrophages to M1 phenotype.