Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications - PubMed
5 hours ago
- #Redox Signaling
- #ROS
- #Cancer Therapy
- Reactive oxygen species (ROS) serve as critical secondary messengers in cellular signaling pathways.
- Dysregulation of redox signaling contributes to malignant transformation and cancer progression.
- Cancer cells exhibit elevated ROS levels due to metabolic activity, mitochondrial dysfunction, and oncogene activation.
- Moderate oxidative stress promotes tumorigenesis by inducing DNA damage and genomic instability.
- Excessive ROS accumulation can trigger programmed cell death mechanisms like apoptosis, autophagy, and ferroptosis.
- ROS modulation is a promising therapeutic strategy in cancer treatment.
- Redox profiling may enhance personalized medicine approaches for better therapeutic efficacy.
- The review explores the dual role of ROS in cancer and redox-based therapeutic advancements.