Dbf4-dependent kinase finetunes Ino80 function at chromosome replication origins - PubMed
5 hours ago
- #DNA replication
- #chromatin remodeling
- #kinase signaling
- The Dbf4-Dependent Kinase (DDK) phosphorylates the MCM complex to initiate DNA replication.
- A mass spectrometry study identified about 400 DDK-dependent phosphorylation targets, including Arp8 of the INO80 chromatin remodeling complex.
- Phosphorylation of Arp8 stabilizes INO80, fine-tunes nucleosome spacing at replication origins, and enhances replication and stress response.