Sensitive CAR T cells redefine targetable CD70 expression in solid tumors - PubMed
4 hours ago
- #CD70
- #solid tumors
- #CAR T cells
- Solid tumor antigen heterogeneity is a major challenge for cancer immunotherapies, including CAR T cells.
- CD70 is a promising target, physiologically confined to immune cell subsets and aberrantly expressed in many cancers.
- Heterogeneous CD70 expression in tumors is epigenetically regulated, ranging from high to very low in individual cells.
- A highly sensitive CD70 receptor, HLA-independent T cell (HIT) receptor, coexpressing CD80 and 4-1BBL for costimulation, efficiently eliminated CD70-heterogeneous tumors.
- This provides a potential strategy to treat a broad range of solid tumors.