Disrupted intrathalamic and thalamocortical structural covariance networks in posttraumatic stress disorder - PubMed
8 hours ago
- #Structural Covariance
- #PTSD
- #Thalamus
- The study investigates structural covariance (SC) patterns of thalamic nuclei in PTSD, using MRI data from 2,784 subjects.
- PTSD is linked to stronger intrathalamic and thalamocortical network strength, with specific connections between limbic thalamus and somatomotor/auditory thalamus.
- PTSD severity correlates with alterations in the lateral pulvinar, while comorbid depression relates to global intrathalamic changes.
- Avoidance symptoms positively correlate with global thalamosubcortical alterations, and hyperarousal symptoms are associated with altered thalamocortical SC involving specific nuclei and cortical regions.
- Individual-level SC analysis reveals distinct thalamic covariance patterns tied to different PTSD symptoms, offering insights for future research on thalamic involvement in psychopathology.