Integration of Epidemiology and Network Toxicology Revealed the Arrhythmogenic Potential of Neonicotinoid Insecticides - PubMed
3 hours ago
- #oxidative stress
- #arrhythmia
- #neonicotinoids
- Arrhythmia is a growing public health concern with increasing prevalence and multifactorial etiology.
- Neonicotinoids (NEOs) are widely used neuroactive insecticides, but their cardiac effects are not well understood.
- Higher concentrations of NEOs were found in arrhythmia patients compared to healthy controls, except for thiamethoxam and clothianidin.
- Coexposure to multiple NEOs increased the risk of arrhythmia and oxidative stress, with dinotefuran (DIN) contributing the most (40.9%).
- Oxidative stress biomarker 8-hydroxy-2'-deoxyguanosine mediated significant portions of the associations between NEO exposure and arrhythmia risk.
- Network toxicology analyses identified oxidative stress, inflammatory response, and endocrine disruption as key pathways in NEO-related arrhythmia.
- Key target genes involved in NEO cardiotoxicity include AKT1, EGFR, GAPDH, CASP3, and HSP90AA1.