Chemoradiotherapy-Integrated Tumor Cell-Derived Microparticles Mediate Tumor Eradication in Malignant Pleural Effusion - PubMed
6 hours ago
- #immunotherapy
- #cancer therapy
- #microparticles
- Researchers developed chemoradiotherapy-integrated tumor cell-derived microparticles (CR-MPs) by loading irradiated tumor cell-derived microparticles (RT-MPs) with drugs like methotrexate (MTX) to treat malignant pleural effusion (MPE), a condition with poor prognosis in advanced cancer.
- CR-MPs, especially MTX-loaded ones, showed superior tumor-killing ability by inducing mitochondrial oxidative stress, immunogenic ferroptosis in tumor cells, reprogramming macrophages to M1 phenotype, and activating dendritic cells via cGAS-STING/NF-κB pathways.
- In mouse MPE models, CR-MPs effectively suppressed tumors, extended survival, and were safe. Combined with immunotherapy, they achieved up to a 70% cure rate, induced long-lasting immune memory, and worked against chemotherapy-resistant tumors.
- The study positions CR-MPs as a novel, precise concurrent chemoradiotherapy platform with high translational potential for clinical MPE management, supported by multiple research grants.