Adipose tissue catecholamine resistance: a metabolic safeguard that challenges weight control - PubMed
5 hours ago
- #Weight loss
- #Adrenergic signaling
- #Lipid metabolism
- Adipose tissue catecholamine resistance involves cellular and molecular adaptations in obesity.
- It dampens adrenergic signaling, potentially protecting tissues from excessive catecholamine stimulation and metabolic stress.
- Reduced adrenergic responsiveness limits lipolysis and thermogenesis, hindering fat mobilization during caloric restriction or increased energy demand.
- While initially adaptive, catecholamine resistance in nutrient excess may promote energy storage and weight persistence in obesity.
- The study explores the neuro-endocrine framework of catecholamine resistance and its implications for metabolic homeostasis and weight regulation in obesity.