Multi-omics profiling of the diabetic human heart reveals coupled dysregulation in lipid metabolism, mitophagy, and extracellular matrix remodeling - PubMed
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- #diabetic cardiomyopathy
- #multi-omics
- #mitophagy
- Multi-omics profiling of diabetic cardiomyopathy (DbCM) identifies coordinated dysregulation in lipid metabolism, mitophagy, and extracellular matrix remodeling.
- Elevated ACSL1 and reduced FASN indicate rewired fatty acid oxidation, with metabolomics showing incomplete oxidation via acylcarnitine/lipid accumulation.
- Significant reduction in mitophagy regulator BNIP3L, inversely correlated with ACSL1, suggests impaired mitochondrial quality control.
- Downregulation of structural proteins like COL5A1, COL5A2, and fibrillin-1 points to disrupted extracellular matrix homeostasis.
- Integrated analysis highlights ACSL1 and BNIP3L as potential therapeutic targets for diabetes-related cardiac dysfunction.