Tumor-Derived Exosomes Deliver Membrane-Bound Fgl2 to Activate FcγRIIB-Mediated Immunosuppression in Myeloid-Derived Suppressor Cells - PubMed
8 hours ago
- #immunosuppression
- #exosomes
- #cancer immunotherapy
- Tumor-derived exosomes (TEX) deliver membrane-bound Fgl2 (mFgl2) to myeloid-derived suppressor cells (MDSCs).
- Fgl2 activates FcγRIIB on MDSCs, enhancing immunosuppressive functions like arginase-1 and iNOS expression, suppressing CD8+ T cell proliferation.
- Blocking Fgl2 or FcγRIIB reduces immunosuppression and tumor growth, with combination therapy (exosome inhibitor, PD-L1 blockade, MDSC depletion) showing synergistic antitumor effects.