Unraveling the potential of targeting methionine metabolism in cancer - PubMed
5 hours ago
- #immunotherapy
- #cancer
- #methionine metabolism
- Methionine metabolism is crucial for cellular homeostasis, affecting protein synthesis, redox regulation, and epigenetic control.
- Cancer cells rely heavily on methionine, especially for S-adenosylmethionine (SAM) synthesis, which supports oncogenic transcriptional programs.
- Methionine adenosyltransferase 2A (MAT2A), an enzyme involved in SAM production, is often overexpressed in tumors.
- Dysregulated methionine metabolism impacts the tumor microenvironment (TME), affecting nutrient competition and antitumor immunity.
- MAT2A is identified as a metabolic vulnerability in cancer, with potential for synthetic lethality-based targeting.
- Methionine-restricted strategies and MAT2A inhibition are emerging as promising interventions that may enhance immunotherapy efficacy.
- The review outlines the clinical potential of methionine-targeted therapies and future research directions in cancer treatment.