Ulcerative colitis, pathophysiological mechanisms and drug repurposing: a new therapeutic dawn-narrative review - PubMed
5 hours ago
- #Ulcerative colitis
- #Drug repurposing
- #Inflammatory pathways
- Ulcerative colitis (UC) is a type of inflammatory bowel disease with rising global prevalence and incidence.
- Multiple pathways are involved in UC pathophysiology, including IL-6/STAT3, mTOR/AMPK, SPHK/S1P, and Nrf2/HO-1.
- Current treatments for UC are not effective for about one-third of patients, prompting research into new therapies and drug repurposing.
- Several drugs, including rosiglitazone, amlodipine, metformin, and others, have shown anti-inflammatory effects beneficial for UC.
- These drugs positively impact gut barrier integrity, oxidative stress, and inflammatory pathways in UC models.
- Understanding the protective mechanisms of these drugs could improve UC treatment strategies.