Microglia protein profiles in CSF across Alzheimer's disease clinical stages - PubMed
14 hours ago
- #Alzheimer's disease
- #Biomarkers
- #Microglia
- Microglia protein profiles in CSF were analyzed across Alzheimer's disease (AD) clinical stages.
- Two CSF cohorts (n = 834) were studied, identifying 109 dysregulated microglia-related proteins.
- Preclinical AD showed enrichment in innate immune processes and cellular recruitment.
- AD dementia revealed adaptive immunity and macrophage responses.
- An 18-protein panel was classified, highlighting distinct changes between preclinical and dementia stages.
- Findings support microglia-based biomarker research for AD staging and understanding microglia dynamics.