A CD57+ CD8 T cell subset links cytotoxic T cell cytotoxicity to fibrotic lung disease in systemic sclerosis - PubMed
5 days ago
- #Autoimmunity
- #Immunology
- #T cells
- Interstitial lung disease (ILD) is a major cause of morbidity and mortality in systemic sclerosis (SSc).
- A specific population of cytotoxic CD8 T cells marked by CD57 expression is expanded in SSc-ILD patients.
- CD57+ T effector memory (TEM) cells show enhanced cytotoxic function when CD155 engages the costimulatory receptor CD226.
- CD57+ TEM cells are present in lung tissue samples from SSc-ILD patients.
- Endothelial cells are identified as a likely source of CD155, activating CD57+ cytotoxic T cells.
- The study suggests CD57+ cytotoxic CD8 T cells as potential mediators of lung injury in SSc-ILD.