Salvia miltiorrhiza extract attenuates cardiorenal syndrome by inhibiting IL-1β mediated cross-talk between heart and kidney - PubMed
5 hours ago
- #Cardiorenal syndrome
- #Inflammation
- #Salvia miltiorrhiza
- Salvia miltiorrhiza extract helps reduce cardiorenal syndrome by blocking IL-1β mediated heart-kidney communication.
- The study used multiple mouse models to test the effects of S. miltiorrhiza root extract on heart and kidney function.
- Salvianolic acid B, the main active component, targets NEU1 in heart cells to reduce inflammation and protect kidney function.
- The extract showed indirect kidney protection by disrupting harmful heart-kidney interactions via the NEU1-TLR4-IL-1β pathway.
- This research provides new insights into how S. miltiorrhiza can be used to treat cardiorenal syndrome by targeting inflammation.