Antimicrobial resistance genes and antibiotic use in chronic lung disease: a bronchoscopy study of the lower airways microbiome - PubMed
6 hours ago
- #Respiratory Microbiome
- #Antimicrobial Resistance
- #Chronic Lung Disease
- Study investigates antimicrobial resistance genes (ARGs) in the lower airways microbiome across chronic lung disease patients and controls.
- Found higher ARG presence in sarcoidosis (65%) and idiopathic pulmonary fibrosis (IPF) (83%) compared to healthy controls (38%).
- Tetracycline resistance was the most common ARG class (33%), followed by beta-lactam and macrolide resistance (both 26%).
- Recent antibiotic use (≤3 months) was significantly associated with increased ARG counts per million.
- Logistic regression showed significantly higher odds of ARGs in sarcoidosis and IPF patients after adjusting for confounding factors.