Potential Strategies for Bacterial Infection Control: Outer Membrane Vesicle Based Bacterial Vaccines - PubMed
5 hours ago
- #bacterial infection
- #immune modulation
- #vaccines
- Bacterial infections are the second leading cause of death worldwide.
- Increase in bacterial resistance and emergence of superbacteria necessitate urgent prevention and treatment strategies.
- Bacterial vaccines are an effective strategy to prevent infections.
- Outer Membrane Vesicles (OMVs) are nanoscale spherical membrane structures produced by bacteria, containing bioactive substances like lipopolysaccharides and peptidoglycans.
- OMVs have inherent adjuvant properties and antigen delivery ability, enhancing both humoral and cellular immune responses.
- OMV surfaces can be engineered to carry and display various antigens, making them an ideal platform for innovative vaccines.
- The review discusses the classification, advantages, and disadvantages of existing bacterial vaccines, and the principles and challenges of OMV-based bacterial vaccines.