A novel Chinese medicine formula against hyperuricemia-induced kidney inflammation involving pyroptosis inhibition via modulating AMPK-TLR4-NLRP3 pathway - PubMed
6 hours ago
- #Chinese Medicine
- #Kidney Inflammation
- #Hyperuricemia
- A novel Chinese medicine formula (GF) was studied for its effectiveness against hyperuricemia (HUA)-induced kidney inflammation.
- GF was observed to reduce pain sensitivity and improve tensile performance in HUA mouse models.
- The treatment significantly lowered levels of uric acid (UA), blood urea nitrogen (BUN), and creatinine (Cre), alleviating kidney injury.
- GF suppressed inflammatory responses by modulating protein expressions related to inflammation and upregulating AMPK phosphorylation.
- It also affected uric acid transporters (UAT) by increasing OAT1 and OAT3 while decreasing URAT1 and GLUT9.
- In vitro studies confirmed GF's role in reducing intracellular UA levels and mitigating inflammation-induced pyroptosis in HK-2 cells.
- The mechanism involves inhibition of the AMPK-TLR4-NLRP3 pathway, suggesting GF as a promising therapeutic for HUA and related kidney complications.