Gut-derived IL-17A via STAT3/RORγt signaling underlies sleep disruption-induced depression: Targeting effects of Schisandrin B therapy - PubMed
5 hours ago
- #Gut-Brain Axis
- #Neuroinflammation
- #Sleep Deprivation
- Sleep disruption induces depression through gut-derived IL-17A signaling via STAT3/RORγt, leading to neuroinflammation.
- Schisandrin B, from Schisandra chinensis, reverses depressive behaviors by restoring gut-brain axis balance and suppressing IL-17A inflammation.
- Clinical and mouse studies show elevated IL-17A and metabolic issues in depression, with Schisandrin B improving gut barrier and neural function.
- Schisandrin B targets MAPK1 and GSK3β, inhibiting STAT3/RORγt, highlighting its potential as a natural immunomodulatory therapy for mood disorders.