VAMP4/STX8 Mediate the Autophagic Secretion of Mitochondria and Promote TAMs Polarization in HNSCC - PubMed
5 hours ago
- #tumor microenvironment
- #extracellular vesicles
- #mitophagy
- Hypoxia promotes mitophagy-dependent extracellular vesicles (EVs) secretion in head and neck squamous cell carcinoma (HNSCC).
- VAMP4 and STX8 are key molecules mediating the autophagic secretion of mitochondria via EVs.
- This secretion promotes tumor-associated macrophages (TAMs) to adopt immunosuppressive phenotypes, reshaping the tumor immune microenvironment.
- High VAMP4/STX8 expression in HNSCC correlates with prognosis and may serve as biomarkers and therapeutic targets.
- Targeting this mitophagy-secretion axis could enhance immunotherapy efficacy in HNSCC.