Dynamic changes in excitability and viability of sporadic and SOD1-related amyotrophic lateral sclerosis iPSC-derived motor neurons - PubMed
4 hours ago
- #iPSC
- #ALS
- #hyperexcitability
- ALS patient-derived motor neurons (MNs) showed significantly higher firing rates than healthy controls (HCs) at 4-7 weeks and 7-9 weeks.
- SOD1-related ALS MNs had higher excitability than sporadic ALS (sALS) MNs and HCs at 4-7 weeks, but matched sALS levels by 7-9 weeks.
- Apoptosis rates were significantly higher in both sALS and SOD1 MNs compared to HCs at Day 30 and Day 60.
- iPSC-derived MNs from both ALS types serve as valuable models for studying ALS mechanisms.