Targeting the lipid metabolism proteins FASN and GPAM in alveolar type II cells decreases lung metastasis - PubMed
12 hours ago
- #AT2 cells
- #lung metastasis
- #lipid metabolism
- Cancer cells in the lung rely on lipids produced by alveolar type II (AT2) cells.
- Breast cancer-derived lung metastases stimulate AT2 cell proliferation and reprogram them into lipid feeder cells.
- The metastasis secretome activates SREBP-1 in AT2 cells, increasing expression of lipid synthesis genes FASN and GPAM.
- Deleting Fasn in AT2 cells or targeting FASN and GPAM systemically reduces lung metastasis growth in mice.
- Targeting AT2 cell lipid metabolism can impair metastasis growth.