Spatial lipidomics identifies α-synuclein-induced lipid changes in an AAV-induced Parkinsonian mouse model - PubMed
6 hours ago
- #Lipidomics
- #Parkinson's disease
- #α-synuclein
- α-synuclein overexpression in a Parkinsonian mouse model induces region-specific lipid alterations in the substantia nigra and striatum, revealed through spatial lipidomics using MALDI-MSI.
- Key changes include alterations in sphingolipids like GM1s, sphingomyelins, and sulfatides, as well as glycerophospholipids with a shift toward reduced polyunsaturated and increased saturated/mono-unsaturated species.
- Increased oxidized phosphatidylcholine lipids (e.g., SAzPC, PAzPC) in the substantia nigra and reduced ether phosphatidylethanolamines there, though they were elevated in the striatum, highlight lipid dyshomeostasis linked to α-synuclein toxicity.