Impact of glycemic optimization on myocardial steatosis and cardiac remodeling in patients with newly diagnosed type 2 diabetes: a longitudinal study - PubMed
4 days ago
- #Glycemic Optimization
- #Cardiac Remodeling
- #Type 2 Diabetes
- Study examines the impact of glycemic optimization on myocardial steatosis and cardiac remodeling in newly diagnosed type 2 diabetes patients.
- Participants underwent a 12-month glycemic optimization protocol including insulin, metformin, empagliflozin, and lifestyle counseling.
- Significant reductions in HbA1c, BMI, and waist circumference were observed, but no significant changes in myocardial triglyceride content (MTGC).
- Cardiac MRI showed improvements in left ventricle ejection fraction and reductions in ventricular volumes.
- Increased indexed LV mass was noted, with no associations between HbA1c improvement and MTGC or cardiac MRI parameters.
- Reductions in BMI and waist circumference were linked to better left atrial strain and LV end-diastolic volume.
- Findings suggest cardiac remodeling changes are more associated with adiposity reduction than glycemic control, highlighting weight management's role in preventing diabetic cardiomyopathy.