Mast cell-derived MIF Polarizes Th17 cells to drive lung adenocarcinoma progression - PubMed
5 hours ago
- #Lung adenocarcinoma
- #Mast cells
- #Th17 cells
- Mast cells (MCs) in lung adenocarcinoma (LUAD) drive disease progression by polarizing Th17 cells via MIF secretion.
- Retrospective analysis showed elevated IL-17 levels in LUAD patients with malignant pleural effusion (MPE).
- MCs and Th17 cells are in closer proximity in LUAD tissues compared to normal lung tissues.
- Single-cell RNA sequencing identified MIF signaling as the key mediator of MC-Th17 interactions.
- Blocking MIF with ISO-1 or stabilizing MCs with cromolyn sodium (CS) inhibited Th17 polarization and tumor progression.
- The MC-MIF-Th17 axis is a promising therapeutic target for LUAD treatment.