Decoding B Cell Signatures of Complete Pathological Response to Perioperative Chemoimmunotherapy in Non-Small Cell Lung Cancer - PubMed
2 days ago
- #Chemoimmunotherapy
- #Non-small cell lung cancer
- #B cell signatures
- Complete pathological response (CPR) correlates with long-term survival after perioperative chemoimmunotherapy (ChIO) in resectable non-small cell lung cancer (NSCLC).
- CPR tumors exhibited a more clonal baseline B cell receptor (BCR) repertoire, better conserved and reinvigorated during neoadjuvant ChIO.
- Patients with CPR tumors displayed a BCR repertoire enriched in class-switched clones, higher diversity, lower clonality, and upregulation of activation-related transcriptional programs in blood.
- Neoadjuvant ChIO was associated with induction of B cell-related genes within tertiary lymphoid structures (TLS) and higher TLS density at surgery.
- Mature-TLSs in CPR tumors were enriched in immune-activation and antigen-presenting pathways, estimated Tfh cells, pDCs, and plasma cells.
- Low-B cell regions from CPR tumors showed higher inferred infiltration of CD8+ T cells, NK cells, and macrophages with reduced neutrophils and Tregs.
- Patients with CPR tumors exhibit a pre-existing and more mature B cell response that develops further during neoadjuvant ChIO.
- BCR metrics are highlighted as promising predictive biomarkers in NSCLC.