Reduced YTHDF2 inhibits PD-L1 expression by stabilizing m6A-containing SPOP mRNA in colorectal cancer - PubMed
5 hours ago
- #YTHDF2
- #PD-L1
- #colorectal cancer
- Reduced YTHDF2 inhibits PD-L1 expression in colorectal cancer (CRC).
- YTHDF2 is upregulated in CRC tissues and associated with worse prognosis.
- YTHDF2 promotes CRC growth in vivo but does not affect cell proliferation, migration, or invasion in vitro.
- Inhibition of YTHDF2 reduces PD-L1 expression and PD-1/PD-L1 binding ability.
- SPOP mRNA is identified as a YTHDF2 target with validated m6A methylation sites.
- YTHDF2 knockdown increases SPOP mRNA stability, leading to higher SPOP expression and lower PD-L1 expression.
- The YTHDF2-SPOP-PD-L1 axis presents a potential target for CRC treatment and anti-PD-1/PD-L1 therapy enhancement.