Phase separation of OPTN initiates mitophagy to orchestrate craniofacial bone mineralization - PubMed
6 days ago
- #Bone mineralization
- #Mitophagy
- #Phase separation
- OPTN's phase separation initiates mitophagy, crucial for craniofacial bone mineralization.
- Loss of OPTN impairs mitophagy and ACP transport in OMSCs, leading to mineralization defects.
- OPTN undergoes LLPS driven by S173 phosphorylation in its NTD, aiding phagophore membrane association.
- UBD in OPTN's CTD promotes LLPS to recruit ubiquitin-modified mitochondria.
- Mutations (S173A, D474N) disrupt OPTN LLPS, inhibiting mitophagy and bone mineralization in models.
- Findings suggest OPTN LLPS links mitophagy to craniofacial development, offering therapeutic potential.