SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3-HELZ2/PPARα-HIF1α Axis to Drive Intervertebral Disc Degeneration - PubMed
6 hours ago
- #SETD1A
- #intervertebral disc degeneration
- #glycolysis
- SETD1A is a key epigenetic regulator in intervertebral disc degeneration.
- SETD1A regulates glycolysis and senescence of nucleus pulposus cells via the H3K4me3-HELZ2/PPARα-HIF1α axis.
- Downregulation of SETD1A reduces H3K4me3 at the HELZ2 promoter, inhibiting HIF1α and impairing glycolysis.
- SETD1A knockdown accelerates cell senescence and aggravates disc degeneration, while overexpression has protective effects.
- The study suggests SETD1A as a promising therapeutic target for treating intervertebral disc degeneration.