Shenkangling alleviates renal fibrosis induced by renal ischemia-reperfusion injury by mitigating mitochondrial damage through modulation of the STING signaling pathway - PubMed
11 hours ago
- #STING signaling
- #mitochondrial damage
- #renal fibrosis
- Shenkangling (SKL) alleviates renal fibrosis caused by renal ischemia-reperfusion injury (RIRI).
- SKL mitigates mitochondrial damage by modulating the STING signaling pathway.
- SKL reduces fibrosis markers and improves mitochondrial function in RIRI models.
- The primary active components of SKL, catalpol and loganin, exhibit anti-fibrosis effects.
- STING inhibition by SKL helps restore mitochondrial membrane potentials and morphology.