Mogrosides from S. grosvenorii ameliorate acute pharyngitis via the PI3K/AKT-NF-κB-NLRP3 signaling pathway and oxidative stress modulation - PubMed
6 hours ago
- #oxidative stress
- #mogrosides
- #anti-inflammatory
- TMG from S. grosvenorii alleviates acute pharyngitis by reducing inflammation and oxidative stress.
- Study in mice shows TMG downregulates PI3K/AKT-NF-κB pathway, inhibits NLRP3 inflammasome, and activates Nrf2/HO-1 antioxidant system.
- In LPS-stimulated RAW264.7 cells, TMG-containing serum reduces nitric oxide, reactive oxygen species, and NLRP3 activation.
- Chemical analysis identifies 41 mogroside constituents in TMG; metabolomics indicates modulation of amino acid pathways.
- Findings support TMG's multi-component synergy for treating pharyngitis, offering pharmacological evidence for clinical use.