Spatial tumor evolution panorama of ovarian cancer - PubMed
5 hours ago
- #ovarian cancer
- #tumor microenvironment
- #metastasis
- Study presents a spatial tumor evolution panorama of ovarian cancer using extensive genomic and transcriptomic data.
- Identifies a Darwinian evolutionary trajectory influenced by hypoxia and immune pressures leading to metastasis.
- Highlights a tripartite ensemble of MMP11+ myCAFs, epithelial cells, and SPP1+ macrophages in ascites and metastases.
- SPP1+ macrophages are predictive of therapeutic responses in clinical trials.
- SPP1-CD44 inhibition identified as a potential therapeutic modulation strategy.
- Findings offer new insights into ovarian cancer's spatial dynamics for improved therapeutic approaches.