Liraglutide reduces the apoptosis of feeding and appetite-suppressing neurons in the hypothalamus of obese rats association with the PI3K/AKT/Foxo1 pathway - PubMed
5 hours ago
- #Liraglutide
- #Obesity
- #Neuroprotection
- Liraglutide, a GLP-1 analogue, reduces apoptosis in hypothalamic neurons of obese rats.
- The study focuses on the PI3K/AKT/Foxo1 pathway as a mechanism for Liraglutide's neuroprotective effects.
- Obese rats on a high-fat diet showed neuronal damage and increased apoptosis, which Liraglutide reversed.
- Liraglutide activates the PI3K/AKT pathway, reduces Foxo1 expression, and balances Bcl-2/Bax apoptotic regulators.
- The treatment also normalized the activity of POMC and NPY/AgRP neurons, key in appetite regulation.
- Findings suggest Liraglutide's potential for neuroprotection and its anti-obesity effects via hypothalamic neuron protection.