Eosinophilic Versus Non-Eosinophilic Acute Exacerbations of COPD and Subsequent Cardiovascular Event - PubMed
6 hours ago
- #COPD
- #Cardiovascular Risk
- #Eosinophils
- Eosinophilic acute exacerbations of COPD (AE-COPD) were associated with a lower one-year risk of major adverse cardiovascular events (MACE) compared to non-eosinophilic AE-COPD.
- The study analyzed 143,517 patients, with 33,761 classified as eosinophilic AE-COPD (blood eosinophil count ≥300/μL) and 109,756 as non-eosinophilic.
- After propensity score matching, the hazard ratio (HR) for MACE was 1.22 for non-eosinophilic AE-COPD vs. eosinophilic AE-COPD, indicating a 22% higher risk in the non-eosinophilic group.
- Eosinophilic AE-COPD also showed reduced risks of specific cardiovascular events like heart failure, acute myocardial infarction, stroke, arrhythmia, and lower all-cause mortality.
- The findings were robust across sensitivity analyses, suggesting blood eosinophil count at exacerbation could help stratify long-term cardiovascular risk in COPD patients.