Liver Kinase B1 in CD11c+ Cells Inhibits Fibrosis in Chronic Pancreatitis via the Oncostatin M Signaling - PubMed
10 hours ago
- #oncostatin M
- #fibrosis
- #chronic pancreatitis
- Lkb1 expression is reduced in CD11c+ cells within fibrotic areas of chronic pancreatitis patient tissues.
- Deletion of Lkb1 in CD11c+ cells worsens pancreatic fibrosis by driving monocytes to become CD11c+CD206+ mixed-phenotype macrophages.
- The CCL2/CCR2 signaling axis is key for the infiltration of these macrophages into fibrotic lesions.
- Lkb1 deletion enhances STAT3 phosphorylation in macrophages, increasing CCL2 secretion and further macrophage recruitment.
- CD11c+CD206+ macrophages activate pancreatic stellate cells via oncostatin M (OSM) binding to OSMR, stimulating CCL2 production.
- Neutralizing OSM suppresses CCL2 secretion and significantly reduces pancreatic fibrosis, suggesting a potential therapeutic target.