Causal effects of gut microbiota and blood metabolites on subtypes of perinatal depression classified based on depressive symptom trajectories: a mendelian randomization study - PubMed
6 hours ago
- #Gut Microbiota
- #Perinatal Depression
- #Mendelian Randomization
- Perinatal depression (PD) is classified into four subtypes based on depressive symptom trajectories: pregnancy, early postpartum, late postpartum, and chronic.
- The study used Mendelian randomization (MR) to assess causal effects of 341 gut microbial taxa and 67 blood metabolites on four PD subtypes in East Asian cohorts.
- 21 gut microbial taxa and five blood metabolites showed suggestive causal associations with specific PD subtypes.
- s_Bacteroides caccae was identified as a potential protective gut microbiota shared between early and late postpartum PD.
- g_Collinsella was identified as a potential risk-associated gut microbiota shared between early and late postpartum PD.
- No blood metabolites were shared across PD subtypes.
- After multiple testing correction, only the protective effect of Bacteroides caccae on early postpartum PD remained statistically significant.
- Mediation analyses showed that s_Prevotella veroralis increased the risk of pregnancy PD by elevating phenylalanine levels.
- s_Bacteroides caccae reduced the risk of early postpartum PD by lowering ornithine levels.
- The study provides evidence for a gut microbiota-blood metabolite-PD subtype regulatory network in East Asian populations.