ACAD8 deficiency promotes pathological cardiac hypertrophy in response to pressure overload by regulating histone isobutyrylation - PubMed
3 hours ago
- #histone modification
- #cardiac hypertrophy
- #metabolic regulation
- ACAD8 deficiency in male mice worsens cardiac hypertrophy and dysfunction under pressure overload.
- Deficiency leads to accumulation of isobutyryl-CoA, increasing histone isobutyrylation, chromatin accessibility, and TEAD2 binding at hypertrophy-related gene promoters.
- Overexpression of ACAD8 in cardiomyocytes reduces isobutyryl-CoA and histone isobutyrylation, mitigating cardiac hypertrophy and dysfunction.
- Findings link ACAD8 deficiency to cardiomyopathy via histone isobutyrylation-mediated transcription regulation.