Perivascular mesenchymal cells instruct ST2+ reparative macrophages to promote endovascular injury-induced neointimal hyperplasia in mice - PubMed
5 days ago
- #neointimal hyperplasia
- #macrophages
- #vascular repair
- Perivascular mesenchymal cells (MSCs) enhance arterial immune response by recruiting ST2+ reparative macrophages in male mice.
- MSCs mediate a macrophage phenotypic switch essential for vascular regeneration via NFκB-dependent IL-33 production.
- IL-33 from MSCs drives Osteopontin (OPN/SPP1) production in ST2+ macrophages, promoting VSMC proliferation and neointima formation.
- Local hydrogel delivery of siRNAs targeting Il33 or Spp1 reduces neointimal hyperplasia, suggesting a therapeutic strategy for vascular diseases.
- The study identifies an IL33-ST2-OPN axis mediating crosstalk between MSCs and macrophages in vascular repair.