Convergence of KRAS Mutations and MTAP Loss in Pancreatic Cancer: Genomic Landscape and Clinical Implications - PubMed
5 hours ago
- #pancreatic cancer
- #KRAS mutation
- #MTAP loss
- Comprehensive genomic profiling has prognostic and predictive value in pancreatic adenocarcinoma (PAAD).
- 24% of high-purity PAAD samples harbor homozygous MTAP deletion, with 18.9% showing co-occurrence of KRAS mutations and MTAP loss.
- KRAS and MTAP co-mutation identifies a subgroup with worse survival, more fibrotic and less immune-enriched microenvironments.
- Common KRAS variants in co-mutated tumors are G12D, G12V, and G12R, with G12R slightly more linked to immune-enriched features.
- MTAP loss in KRAS-mutant PAAD represents an immune-excluded subtype with poor prognosis.