Drug-induced perioperative malignant hyperthermia: a real-world study based on the Food and Drug Administration Adverse Event Reporting System (FAERS) database - PubMed
4 hours ago
- #FAERS
- #malignant hyperthermia
- #perioperative
- Study examines drug-induced perioperative malignant hyperthermia (MH) using FAERS database from 2005-2024.
- 769 perioperative MH cases reported, with 100 (13%) being fatal.
- 26 distinct drugs linked to perioperative MH, 17 showing positive signals in disproportionality analysis.
- Inhalation anesthetics most frequently associated with MH, followed by muscle relaxants, general anesthetics, and opioid anesthetics.
- Top five drugs by reported cases: sevoflurane (26.79%), isoflurane (25.88%), propofol (9.62%), succinylcholine (6.63%), fentanyl (4.68%).
- Muscle relaxants showed an increasing trend in MH and fatal MH reports over the study period.
- Study emphasizes need for continued vigilance and individualized risk assessment in perioperative settings.