Human serum albumin and biological fluids reduce cefiderocol activity in carbapenem-resistant Gram-negative bacteria - PubMed
5 hours ago
- #Human Serum Albumin
- #Cefiderocol
- #Carbapenem-Resistant Pathogens
- Human serum albumin (HSA) reduces cefiderocol (FDC) activity in carbapenem-resistant Gram-negative bacteria.
- HSA exposure alters bacterial physiology, reducing biofilm formation and modulating β-lactam resistance genes.
- FDC uptake relies on siderophore-mediated transport, and HSA's iron content affects bacterial susceptibility.
- Time-kill assays show HSA attenuates FDC activity, allowing regrowth in multiple bacterial species.
- Human biological fluids with high protein content similarly reduce FDC efficacy.
- Transcriptional analyses indicate downregulation of iron uptake genes, affecting siderophore-dependent drug uptake.
- Host proteins and fluid environments significantly modulate FDC activity, impacting treatment strategies.