Mendelian Randomization Identified SLC2A9 as a Novel cis-eQTL-Mediated Susceptibility Gene in Suppressing Renal Cancer and Its Related Metabolic Mechanisms - PubMed
6 hours ago
- #Mendelian randomization
- #Metabolic mechanisms
- #Renal cancer
- Mendelian randomization (MR) analysis combined with eQTLs and cis-eQTLs identified SLC2A9 as a novel susceptibility gene suppressing renal cancer (RC).
- SLC2A9 eQTL was significantly associated with lower risks of RC, validated across multiple datasets including IEU OpenGWAS, eQTLGEN, and GTEx Whole Blood.
- The study confirmed SLC2A9's antitumor role in RC through mRNA and protein expression levels in TCGA-KIRC and CPTAC-KIRC datasets.
- Five metabolites were identified as mediators, revealing potential metabolic mechanisms of SLC2A9 eQTL in RC.
- The findings suggest SLC2A9 as a potential drug target for RC, with further investigation needed into the identified metabolic pathways.