Exercise inhibits proliferation and induces apoptosis of lung adenocarcinoma cells via the POU2F2-SPOCD1-PI3K/AKT signaling axis - PubMed
4 days ago
- #Exercise
- #Lung Adenocarcinoma
- #PI3K/AKT Pathway
- Exercise inhibits lung adenocarcinoma (LUAD) progression by downregulating the transcription factor POU2F2.
- POU2F2 is elevated in LUAD cells and promotes proliferation and survival by activating the SPOCD1 promoter.
- The POU2F2-SPOCD1 axis enhances PI3K/AKT pathway signaling, contributing to LUAD cell survival.
- Knockdown of POU2F2 or SPOCD1 reduces proliferation and increases apoptosis in LUAD cells.
- In vivo studies show that POU2F2 knockdown inhibits tumor growth and Ki67 expression.
- The POU2F2-SPOCD1-PI3K/AKT axis may serve as a promising therapeutic target for LUAD.