αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - PubMed
2 hours ago
- #histone acetylation
- #DNA repair
- #α-ketoglutarate
- αKG depletion sensitizes HR-proficient cells to DNA-damaging agents by regulating histone acetylation.
- TMLHE, an αKG-dependent enzyme in carnitine synthesis, is crucial for survival of HR-proficient cells under DNA damage.
- αKG-mediated carnitine synthesis drives histone acetylation, promoting homologous recombination for DNA repair.
- High TMLHE or acetylcarnitine levels correlate with worse progression-free survival in patients receiving DNA-damaging treatments.