Stress-induced OMA1-mediated cleavage of AIFM1 suppresses cell growth by controlling mitochondrial OXPHOS activity - PubMed
8 hours ago
- #AIFM1
- #OMA1
- #mitochondrial stress
- The mitochondrial metalloprotease OMA1 cleaves AIFM1 under stress conditions.
- OMA1-mediated cleavage of AIFM1 reduces its interaction with oxidative phosphorylation subunits, decreasing respiratory activity and impairing cell growth.
- Under steady-state conditions, AIFM1 helps import proteins, especially complex I subunits, via the TIM23 complex to protect the mitochondrial proteome.
- Stress-induced AIFM1 processing and similar mitochondrial proteome changes are observed in the lungs of virally infected mice.