Concentrated Angelica sinensis pills ameliorate ovarian insufficiency by promoting vascular remodeling via inhibiting CYP1B1/ACSL4-mediated ferroptosis - PubMed
4 days ago
- #traditional Chinese medicine
- #angiogenesis
- #ferroptosis
- Concentrated Angelica sinensis pills (Ang) improve ovarian insufficiency by promoting vascular remodeling.
- Ang works by inhibiting CYP1B1/ACSL4-mediated ferroptosis in ovarian vascular endothelial cells.
- The study used a multi-omics approach, including RNA sequencing and lipidomics, to identify key pathways.
- Ang restored ovarian function in rats, improving estrous cyclicity, hormonal profiles, and folliculogenesis.
- Key therapeutic pathways identified include ferroptosis, lipid metabolism, and angiogenesis.
- Ang mitigated oxidative stress by regulating polyunsaturated fatty acid oxidation and arachidonic acid metabolism.
- The study suggests Ang as a novel therapeutic strategy for premature ovarian insufficiency (POI).